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Richter transformation remains an ominous occasion for people with CLL, specifically when it is clonally connected with the original CLL, mainly because none of the recently approved novel agents is truly powerful. Indeed, ailment transformation is a relatively popular cause of failure to gain from these drugs.ninety,128,129 Histological affirmation is always advisable as it can guidebook prognosis (i.e., Hodgkin lymphoma and clonally unrelated tumors have far more favorable prognosis).
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